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Falcon in Eagles' Country27 novembre 晚睡有风险，大家需谨慎 所以，我现在要去睡觉 Nature Cancer Review December 2009 Volume 9 Number 12 Metabolism and cancer: the circadian clock connection Saurabh Sahar & Paolo Sassone-Corsip 886 | doi:10.1038/nrc2747 Circadian rhythms govern a remarkable variety of metabolic and physiological functions. Accumulating epidemiological and genetic evidence indicates that the disruption of circadian rhythms might be directly linked to cancer. Intriguingly, several molecular gears constituting the clock machinery have been found to establish functional interplays with regulators of the cell cycle, and alterations in clock function could lead to aberrant cellular proliferation. In addition, connections between the circadian clock and cellular metabolism have been identified that are regulated by chromatin remodelling. This suggests that abnormal metabolism in cancer could also be a consequence of a disrupted circadian clock. Therefore, a comprehensive understanding of the molecular links that connect the circadian clock to the cell cycle and metabolism could provide therapeutic benefit against certain human neoplasias. SummaryCircadian rhythms are endogenously generated rhythms that occur with a periodicity of around 24 hours.There is an intimate link between the disruption of circadian rhythms and cancer. The circadian clock regulates key aspects of cell growth and survival, including the cell cycle, DNA damage responses, cellular senescence and metabolism.Several cell cycle genes, such as WEE1, MYC and cyclin D1, are regulated by the circadian clock. This could be one way by which the circadian clock gates cell division.Key clock proteins, such as PER1 and timeless, interact with proteins involved in the DNA damage responses. DNA damage itself can reset the clock.Cellular metabolism is altered in cancer. Several key metabolic genes are under circadian regulation. Recent findings that SIRT1, a key regulator of metabolism, is an integral part of the clock machinery suggest that the circadian clock can regulate cellular metabolism in multiple ways.The transcriptional negative feedback loop that regulates the circadian clock is interlocked with an enzymatic feedback loop in which SIRT1 regulates the levels of its own cofactor, NAD+.30 giugno 一天看了三部电影Transformer2还是很赞的。擎天柱牺牲之前那段左冲右突的镜头很有大侠的味道。不过中间的搞笑噱头有点太多了，冲淡了主题。 Angles and Demons我觉得比达芬奇密码好看。不过教皇内侍应该是老教皇的儿子的。这个好像在电影里面没有出现。最后的结局还是给梵蒂冈保留了很多希望与美好的，和原著比起来，我更喜欢这个结局。中间空拍圣彼得大教堂和夜间的天使堡两个镜头都很不错。看了又想去梵蒂冈了。 Year One比较无聊，和之前被评论的一样。笑料太过分散+一个无聊的主题。其实中间很多圣经的背景因该可以好好发掘的。 27 gennaio 远离ＶＴ，更远离ＶＴ男晚上看BBS居然看到这么一个贴。我还能说什么。只有笑笑，同时用力鄙视下作者的智商。 可惜了，ID里面居然还有一个我挺喜欢的英文名字。
发信人: lilysarah (lily), 信区: Virginia 标 题: Re: 雷死我了！这版里居然这么多人为杀人犯说话？！ 发信站: BBS 未名空间站 (Mon Jan 26 07:58:50 2009) 我也是跟着一个“十大”帖第一次跟到这个版 ＶＴ的校长还要呼吁说ＶＴ其实是一个安全的校园。。。 看了这一版的帖子，就可以知道这话有多可笑了。 就算正常人跑这种地方估计都会变态。 ＭＭ们珍惜生命，远离ＶＴ，更远离ＶＴ男。。。 22 gennaio VT又出事了主校区Blacksburg真是流年不利，尤其是亚裔更是流年不利。这次摊到中国人头上了。凶手已经被证实是中国学生，男性。死者是女性，估计也是中国人。估计是感情问题。不知道大家是不是要得出这个结论了：不要惹从VT来的亚洲人。。。不过我对毛主席发誓，俺们大部分同学还是好人，爱国爱人民爱社会来自VT官方网站的消息如下，截止到012208 12:25 AMBLACKSBURG, Va., January 21, 2009 -- On Wednesday, Jan 21, at 7:06 p.m., Virginia Tech Police received a 911 call reporting that a female was being assaulted in the cafe at the Graduate Life Center at Donaldson-Brown (the Au Bon Pain restaurant located on the first floor).Upon arrival at 7:10 p.m., officers encountered the suspect at the crime scene. He was immediately taken into custody.The suspect is an Asian male graduate student, Haiyang Zhu, age 25, from China.The victim is an Asian female graduate student. Her identity is being withheld pending notification of next of kin.Virginia Tech Police entered the scene to discover the victim who was deceased. The murder weapon, a knife, was left at the scene and retrieved by police. Zhu was charged with first-degree murder and is being held without bond.Virginia Tech Police are currently interviewing witnesses. Preliminary indication is that the victim and the suspect knew each other.The Graduate Life Center first floor is currently secured. Residents of the hall will be allowed to enter and leave their rooms. Others are asked to stay away from the area tonight. The building will be open tomorrow.Students are reminded that campus counseling resources are available through the Cook Counseling Center (231-6557), the Dean of Students Office (231-3787) and the Graduate Life Center, which will have counselors available beginning at 8 a.m. Thursday morning.In light of recent events on campus, students are encouraged to stay close to friends and be in contact with one’s family.If you have any information related to this case, please contact the Virginia Tech Police at 540-231-6411.As additional information is available, it will be posted to the Virginia Tech homepage.Contact Larry Hincker at hincker@vt.edu or (540) 231-5396.##09038##更新：凶手是中国学生朱海洋，PhD学生，25岁,来自宁波，去年秋季入学，学习农业经济学死者是中国学生杨馨，研究生，22岁, 来自北京，刚入学两个星期，学习会计根据警方的消息：女生基本上是被斩首的。也不知道两个星期怎么能有这么大的仇恨。今天校方的官方消息BLACKSBURG, Va., January 22, 2009 -- Virginia Tech Police have confirmed the name of the female graduate student murdered yesterday evening in the university's Graduate Life Center at Donaldson Brown.She was Xin Yang, a 22-year-old graduate student from Beijing, China. She had just arrived at Virginia Tech Jan. 8 to begin her studies in accounting in the Pamplin College of Business. She was a resident of the Graduate Life Center.Yang was killed at the Au Bon Pain restaurant on the first floor of the Graduate Life Center at approximately 7 p.m. Wednesday evening. Haiyang Zhu, age 25, from Ningbo, China, was charged with first-degree murder and is being held without bond at Montgomery County jail. He was a Ph.D. graduate student majoring in agricultural and applied economics. He began his studies at Virginia Tech at the start of the 2008 fall semester. Based on emergency contact records maintained by the university, it is known that Zhu and Yang knew each other.They were in the Au Bon Pain restaurant when he attacked her. Witnesses indicated no signs of argument and that Zhu attacked her with a knife.Zhu had not been under review or had come before the workings of the Virginia Tech Police Department, or the Town of Blacksburg Police Department, or the university’s Threat Assessment Team or CARE Team.The victim’s mother, who is in China, was notified last night via telephone.University leadership remains concerned about the welfare of the university student community, and particularly the community of Chinese Scholars. The university has counselors on the scene at the Graduate Life Center to assist students, staff, faculty, or others who seek assistance.Counselors will be available to support faculty and staff on Friday, Jan. 23 from 10 a.m. to 4 p.m. in the Jamestown room in Squires Student Center. Faculty and staff may also call Employee Relations at 231-9331 or ValueOptions at 866-725-8279 for support. Information about dealing with the emotional response to traumatic events can be found at the ValueOptions website and at the Achieve Solutions website.The crime scene is secured, but Graduate Life Center residents are free to come and go. Police interviewed several witnesses and are providing counseling support and assistance.校长的声明To the campus communityOur university community was shocked by a brutal murder Wednesday night at the Graduate Life Center. The suspect is in custody and the nature of the incident points to an isolated, very personal tragedy. Our hearts go out to the victim and her family. An act of violence like this one brings back memories of the April 16 tragedy and I have no doubt that many of us feel especially distraught.Once again we are challenged as a community to offer support to one another as we process this recent event. Once again we will rise to the occasion.We encourage students to take full advantage of counseling services at the Cook Counseling Center (231-6557) and we are providing onsite counseling to faculty, staff, and students at the Graduate Life Center in Room B. The Dean of Students Office can also provide assistance to students (231-3787).The campus will remain open and classes will be held on the regular schedule. We will keep you informed about services or other memorials after we have a chance to learn of the family s plans and wishes. At times like this we are reminded how important friends and family are during a tragedy. We will continue to do everything we can to support the Virginia Tech family.President Charles Steger学校给中国社区的信每位在弗吉利亚理工大学的, 都在悲伤和惊愕有关昨晚发生的悲剧. 我要你们记得Cranwell 国际中心会24小时为大家服务. 我们的手机号码是540 230 8747, 办公室是231-6527. 我正在与学校各方办理这件事. 我很愿意与你们交谈.新闻媒体会要访问你们, 你们不必要与他们谈话. 可以叫他随时与我联系.中国学生会的信尊敬的各位会员，昨天晚上7:00PM在VT再次发生了一场悲剧，我们很遗憾地获悉，这次悲剧的疑犯和受害者都是中国学生。具体细节请参看黑堡警方公布的消息http://www.vtnews.vt.edu/story.php?relyear=2009&itemno=40。在此我们向死者表示深切的哀悼，向悲剧双方的家人和朋友致以亲切的慰问。同时，我们希望这次事件不要给黑堡华人社区带来过多的负面影响，干扰大家的生活和学习。请大家保持安定和冷静，以积极的态度共同度过这次难关。由于事件仍在警方调查当中，请大家不要过多对事件好奇而随意打听或者散播，以免干扰警方调查。信息以Virginia Tech官方的公布为准。我们呼吁广大同学互帮互助，团结一致。如果在生活、学习上遇到困难，请及时找身边的朋友或者联谊会寻求帮助。希望大家顺利的度过各自的海外求学生涯。-弗吉利亚理工大学中国学生学者联谊会 |
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